Bio 12
Human Physiology
Dr. Street
Name:__________________________
Unit 2- Show what you know!
a
b
c e d
Above is a two neuron chain: a pre-synaptic neuron and a post-synaptic neuron. Using your scantron, mark in the appropriate answer(s). 1. Where would the “all or none” decision be made? B 2. At what location(s) are ligand operated channels found? A 3. At what location(s) are voltage operated channels found? B, C, D 4. Specifically, where are calcium voltage operated channels found? D 5. At what location(s) are Sodium-Potassium (Na+/K+) ATPases found? A, B, C, D 6. Site where AChE is found. E 7. At what location(s) could you detect an action potential? B C D 8. At what location(s) would you detect local, or graded, potentials? A 9. At what location(s) would curare target? A 10. At what location(s) would lidocaine target? B, C 11. At what location(s) would the botulinum toxin target? D Use these answer selections as you consider the following questions: A. EPSP AB. Resting memb. Pot. BD. Action potential
B. hyperpolarization AC. IPSP BE. downstroke
C. depolarize AD. upstroke CD. threshold
D. repolarize AE. cholinergic CE. All parts
E. adrenergic BC. metabotropic DE. ionotropic
12. A neurotransmitter opens a chloride ligand operated channel, the cell would have this type of postsynaptic graded potential. AC 13. This cell would be get closer to threshold (Mark “A” for True or “B” for false). B 14. A neurotransmitter opens a potassium ligand operated channel, the cell would have this type of postsynaptic graded potential. AC 15. This cell would be get closer to threshold (Mark “A” for True or “B” for false). B 16. A neurotransmitter binds to a metabotropic receptor and PKA is ultimately activated, which type of neurotransmitter likely bound? E 17. Continuing with the previous question, the PKA phosphorylates a potassium channel and deactivates it what will happen to the membrane potential? C 18. This portion of an action potential tracing represents rapidly opening sodium channels. AD 19. This term refers to the potential at which voltage operated sodium channels open. CD 20. This “steady- state” value of this reflects that the cell membrane is more permeable to potassium than sodium. AB 21. This portion of an action potential tracing represents that the cell is rapidly becoming more permeable to potassium. BE 22. This portion of an action potential tracing reflects that potassium voltage operated channels are slow to close and as a result, the inside of the cell becomes more negative. B
Continued…. A. EPSP AB. Resting memb. Pot. BD. Action potential
B. hyperpolarization AC. IPSP BE. downstroke
C. depolarize AD. upstroke CD. threshold
D. repolarize AE. cholinergic CE. All parts
E. adrenergic BC. metabotropic DE. iontotropic
23. During which parts of an action potential would the sodium/potassium ATPase be functional? CE 24. This term describes the temporary reversal of the resting membrane potential. BD 25. A postganglionic parasympathetic neuron would release this type of neurotransmitter. AE 26. Preganglionic neurons release this type of neurotransmitter. AE 27. The receptor on the post-ganglionic neuron would be of this functional classification. DE 28. The receptors on involuntary effector cells would be of this functional classification. BC 29. Receptors that activate second messengers are this functional classification. BC 30. True or False (mark “A” or “B”): The nAChR is an example for the previous question. B 31. The mAChR is this type of functional receptor. BC Use these drug choices to answer the following questions: B. DFP C. neostigmine AB. albuterol AC. phentolamine AD. pilocarpine BD. Tetrodotoxin BE. Saxitoxin CD. lidocaine (TTX) (SXT) 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45.
46. 47.
D. phenylephrine AE. atropine CE. Botulinum toxin
E.propranolol BC. Tetanus toxin DE. isoproterenol
This is an alpha1 blocker and when used on the iris, the pupil constricts. AC This is an asthmatic’s drug—it stimulates only B2 receptors on the lung. AB Fugu fans be warned ! Get a good chef who knows how to prepare puffer fish. BD A dentist’s choice drug to block voltage gated sodium channels. CD This toxin directly inhibits synaptic vesicles from exocytosing. CE A drug given for asthma or bronchitis but has a nasty side affect on the heart because it stimulates B1 receptors as well. DE This is a drug given to patients with hypertension. It blocks sympathetic B1 receptors. Careful not to give it to asthmatic patients! E This drug is the new formula for sudafed. It is a good decongestant because it stimulates alpha 1 receptors. D True or False : The drug in the question above works as a decongestant because it vasodilates blood vessels in the nasal cavity. B True or False : The old formula for Sudafed was “pseudoephedrine.” Taking this drug along with an MAOI is fine—the patient won’t overdose on an adrenaline high. B A patient exposed to this drug would require a ventilator until new AChE was synthesized. B A patient taking this drug would “ooze” from every orifice and pore if their dose was too strong. AD This toxin and black widow’s venom work in similar ways: ultimately leading to spastic paralysis. BC – (the toxin causes decreased IPSP’s by blocking inhibitory neuron release but the black widow venom cause MORE excitatory neurotransmitter release. Either way, the somatic motor neuron is experiencing more EPSP’s). If this drug were injected into a man’s penis, we would see engorgement (erection). AC This drug blocks the parasympathetic nervous system and in doing so, allows more control of the body by the sympathetic nervous system. AE
