Cri Du Chat (Cat's Cry Syndrome) Lucas Rondenet, Ian Durden, Claudio Ciardiello
What is Cri Du Chat? • A rare chromosome disorder in which part of the fifth chromosome is missing. • 1 in 37,000-50,000 births are affected. • Cri Du Chat is slightly more common in females. • When an infant is born with Cri Du Chat, the infant cries like a cat meowing.
Signs and Symptoms of Cri Du Chat • The size of chromosome 5 depleted is related to how severe mental retardation and development delay can be. • Feeding problems • Low birth weight • Poor growth • Severe cognitive, speech, and motor delays • Hyperactive, aggressive, tantrums, and repetitive movements • Odd facial features • Excessive dribbling • May also be born with heart defects.
Kids with Cri Du Chat
Karyotype for Cri Du Chat
What Would My Child Look Like? Physical Characteristics: Parent 1: Parent 2: Ian Durden Megan Fox Brown Hair (BBCC): Brown Hair (BBcc)
BB= 2 Dominant Alleles for Brown Hair BB= 2 Dominant Alleles for Brown Hair CC= 2 Dominant Alleles for Curly Hair cc= 2 Recessive Alleles for Straight Hair Brown Skin Color (Bb): White Skin Color (bb) Aa= Heterozygous for Brown Skin aa= 2 Recessive Alleles for White Skin
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• There is no specific treatment for this syndrome. • This mental retardation must be addressed and can't be avoided. • Counseling is available and recommended for the parents. • Speech and physical therapy may be particularly useful for children with CDC. • Although it is rarely inherited to the offspring, parents with family history of Cri Du Chat should consider genetic counseling.
Punnett Squares BC Bc
Bc
a
A
BC
BBCc
BBCc
Brown/ Curly
Brown/ Curly
a
BBCc
BBCc
a
Brown/ Curly
Brown/ Curly
Aa
aa
Brown Skin
White Skin
Aa
aa
Brown Skin
White Skin
This boy has odd facial features and a small head. He looks this way because his fifth chromosome is lacking in size. His father is black and his mother is white, therefore, he is light skinned.
Links Used • http://www.specialchild.com/archives/dz-012.html • http://ghr.nlm.nih.gov/condition=criduchatsyndrome • http://www.nlm.nih.gov/medlineplus/ency/article/0 01593.htm#Treatment • http://www.wikipedia.org/ • http://www.blinn.edu/socialscience/LDThomas/feldman/ handouts/0203hand.htm • http://www.google.com/
