Hematopoiesis January 31–February 4, 2017 | Fairmont Banff Springs | Banff, Alberta | Canada Scientific Organizers: Catriona H.M. Jamieson, University of California, San Diego, USA Andreas Trumpp, German Cancer Research Center, Germany Paul S. Frenette, Albert Einstein College of Medicine, USA Since the discovery that hematopoiesis could be established by a single cell over five decades ago, advances in model systems, sequencing, reprogramming and genome editing technologies have enabled precise molecular characterization of regulators of hematopoiesis. These discoveries have informed and accelerated implementation of clinical trials for a broad array of benign and malignant hematologic disorders, including bone marrow failure syndromes and leukemia, as well as guided the development of molecular prognostication strategies. This Keystone Symposia meeting will bring together basic, translational and clinical researchers to discuss key regulators of hematopoietic stem and progenitor cell ontogeny, cell fate specification and self-renewal during homeostasis, stress and malignant transformation. The relative importance of cell-autonomous genetic, epigenetic, transcriptional and post-transcriptional hematopoietic regulatory mechanisms as well as local niche or systemic factors will be presented by international leaders in the field of hematopoiesis and stem cell biology. The culmination of innovative genome editing, reprogramming, single-cell sequencing and imaging in different model systems to unravel essential regulators of hematopoiesis will be highlighted. This meeting should provide a vital opportunity for forging collaborations between researchers from disparate disciplines and result in novel insights from a plethora of model systems that will enable investigators to address basic, translational and clinical hematopoiesis research challenges. Session Topics: • Development • HSC Versus Progenitor Contribution to Hematopoiesis • Microenvironment • Epigenetics and Transcription
• Directed Differentiation and Expansion • Genome and Transcriptome Editing in Normal and Malignant Progenitors • Hematopoietic Malignancies • DNA Damage, Repair and Aging
Scholarship Application & Discounted Abstract Deadline: October 4, 2016 Abstract Deadline: November 1, 2016 Discounted Registration Deadline: December 1, 2016
Note: Scholarships are available for graduate students and postdoctoral fellows and are awarded based on the abstract submitted.
Meeting Hashtag: #KShemato
www.keystonesymposia.org/17B1
www.keystonesymposia.org/meetings | 1.800.253.0685 | 1.970.262.1230 a 501(c)(3) nonprofit educational organization
KEYSTONE SYMPOSIA on Molecular and Cellular Biology
Hematopoiesis (B1) January 31-February 4, 2017 • Fairmont Banff Springs • Banff, Alberta, Canada Scientific Organizers: Catriona H.M. Jamieson, Andreas Trumpp and Paul S. Frenette Sponsored by Bayer HealthCare Pharmaceuticals Abstract & Scholarship Deadline: October 4, 2016 / Abstract Deadline: November 1, 2016 / Discounted Registration Deadline: December 1, 2016
TUESDAY, JANUARY 31 Arrival and Registration WEDNESDAY, FEBRUARY 1 Welcome and Keynote Address *Catriona H.M. Jamieson, University of California, San Diego, USA Leonard I. Zon, HHMI/Boston Children's Hospital, USA Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment Development *Catriona H.M. Jamieson, University of California, San Diego, USA David Traver, University of California, San Diego, USA Birth of Stem Cell Robert A.J. Signer, University of California, San Diego, USA Translational Control of Hematopoietic Stem Cells Hanna K.A. Mikkola, University of California, Los Angeles, USA The Path from Hemogenic Endothelium to Hematopoietic Stem Cells Linda T. Vo, Boston Children's Hospital, Harvard Medical School, USA Short Talk: Unlocking Definitive Hematopoietic Potential via Epigenetic Modulation Lucas Greder, University of Oxford, UK Short Talk: Chromatin Accessibility and Expression Profiling of the Endothelial-to-Hematopoietic Transition
Irving L. Weissman, Stanford University, USA Targeting Don’t Eat Me Signals in Malignant Hematopoiesis Laura M. Calvi, University of Rochester Medical Center, USA Short Talk: Age-and Region-Dependent Architectural Remodeling of Niche Constituents in the Hematopoietic Microenvironment Contributes to Hematopoietic Stem Cell Aging Michael Poulos, Weill Cornell Medical College, USA Short Talk: Rejuvenation of the Aged Vascular Niche to Enhance Hematopoietic Function Epigenetics and Transcription Andreas Trumpp, German Cancer Research Center, Germany Human Haematopoietic Stem Cell Differentiation is a Continuous Process without Discrete Progenitor Populations *Maria E. Figueroa, University of Miami Miller School of Medicine, USA Epigenetic Deregulation in the Aging Hematopoietic Stem Cell Scott A. Armstrong, Dana-Farber Cancer Institute, USA Histone Modifications and Gene Expression in Leukemia Iannis Aifantis, New York University School of Medicine, USA The Missing Lncs: Regulation of Blood Cell Transformation by LncRNAs Poster Session 2 FRIDAY, FEBRUARY 3
HSC Versus Progenitor Contribution to Hematopoiesis Directed Differentiation and Expansion *Andreas Trumpp, German Cancer Research Center, Germany *E. Camilla Forsberg, University of California, Santa Cruz, USA Bloody Commitments: Hematopoietic Stem Cell Fate Decisions John E. Dick, Princess Margaret Cancer Centre, Canada Mechanistic Insight Into Human Hematopoietic Lineage Determination Derrick J. Rossi, Harvard University, USA Diminished Apoptotic Priming Underlies Increased Survival of Aged Adolfo Ferrando, Columbia University, USA Hematopoietic Stem Cells in Response to DNA Damage Mechanisms of Clonal Evolution and Relapse in Acute Lymphoblastic Leukemia Dan S. Kaufman, University of California, San Diego, USA Pluripotent Stem Cells to Model Human Hemato-Lymphoid Fernando D. Camargo, Boston Children's Hospital, USA Development Clonal Analysis of Hematopoietic Development Melanie Mumau, Columbia University, USA Bilyana Stoilova, Weatherall Institute of Molecular Medicine, Short Talk: NR4A1 Identifies a Population of Multipotent Progenitors University of Oxford, UK in the Spleen that Restrict Erythropoiesis Short Talk: Functional and Transcriptional Heterogeneity of Human Hemopoietic Lympho-Myeloid Progenitors at the Single Cell Level Gabriela Pregernig, Massachusetts Institute of Technology, USA Short Talk: GATA1 and The Cohesin Complex Cooperate to Regulate Poster Session 1 Erythroid Gene expression Katie Matatall, Baylor College of Medicine, USA THURSDAY, FEBRUARY 2 Short Talk: Batf2 is a Mediator of Stress-Induced Terminal Microenvironment Differentiation Driving Hematopoietic Stem Cell Depletion Following Chronic Infection *Paul S. Frenette, Albert Einstein College of Medicine, USA HSC Niche and its Regulation by Long-Range Signals Genome and Transcriptome Editing in Normal and Malignant David T. Scadden, Massachusetts General Hospital and Harvard Progenitors University, USA *Derrick J. Rossi, Harvard University, USA Hematopoietic Cell Fate is Clone Specific and Epigenetically Catriona H.M. Jamieson, University of California, San Diego, USA Constrained: Implications for Concepts of the Bone Marrow Niche RNA Editing and Malignant Reprogramming Emmanuelle Passegué, University of California, San Francisco, USA Carlo M. Croce, Ohio State University, USA Niche Maintenance of Malignant Hematopoiesis MicroRNA Dysregulation to Identify Therapeutic Targets
* Session Chair † Invited but not yet accepted Program current as of January 12, 2017. Program subject to change. Meal formats are based on meeting venue. For the most up-to-date details, visit www.keystonesymposia.org/17B1.
KEYSTONE SYMPOSIA on Molecular and Cellular Biology
Hematopoiesis (B1) January 31-February 4, 2017 • Fairmont Banff Springs • Banff, Alberta, Canada Scientific Organizers: Catriona H.M. Jamieson, Andreas Trumpp and Paul S. Frenette Sponsored by Bayer HealthCare Pharmaceuticals Abstract & Scholarship Deadline: October 4, 2016 / Abstract Deadline: November 1, 2016 / Discounted Registration Deadline: December 1, 2016
Daniel G. Tenen, Cancer Science Institute, Singapore Regulation of Myeloid Transcription Factors, DNA Methylation and Leukemia by Noncoding RNA Laura PMH de Rooij, McMaster University, Canada Short Talk: Unraveling the Importance of RNA Binding Proteins in Leukemic Stem Cells by CRISPR-Cas9 Screening Poster Session 3 SATURDAY, FEBRUARY 4 Hematopoietic Malignancies Ravi Majeti, Stanford University, USA Stem Cells in Human AML *Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA Clonal Hematopoiesis during Aging Tannishtha Reya, University of California, San Diego, USA In vivo Imaging of Regulators of Normal and Leukemia Stem Cell Symmetric and Asymmetric Division Luigi M. Naldini, San Raffaele Telethon Institute, Italy Genetic Engineering of Hematopoiesis for Treating Human Diseases Toshio Kitamura, University of Tokyo, Institute of Medical Science, Japan Short Talk: Disruption of EZH2 Induces Myelodysplastc Syndromes (MDS) in Mice via Derepression of ABC-G2 Virginia Turati, University College London Cancer Institute, UK Short Talk: Single-Cell Analysis of Clonal Dynamics of childhood ALL DNA Damage, Repair and Aging *Amy J. Wagers, Harvard University, USA Intrinsic and Extrinsic Signals Regulating Stem Cell Aging Michael Milsom, HI-STEM/DKFZ, Germany A Rude Awakening: Stem Cell Depletion in Response to Stress. Elaine Mardis, Nationwide Children’s Hospital, Ohio State University, USA AML Genomics: Clinical Translation from Large-Scale Discovery Meeting Wrap-Up: Outcomes and Future Directions (Organizers) SUNDAY, FEBRUARY 5 Departure
* Session Chair † Invited but not yet accepted Program current as of January 12, 2017. Program subject to change. Meal formats are based on meeting venue. For the most up-to-date details, visit www.keystonesymposia.org/17B1.
